ELK Biotechnology CSB rabbit pAb
ERCC6 단백질을 인식하는 rabbit polyclonal antibody로 IHC, IF, ELISA에 적합. 인간, 랫, 마우스 반응성. 핵 내 DNA 수선 관련 단백질 연구에 활용 가능. -20°C에서 1년 보관 가능.
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ELK Biotechnology CSB rabbit pAb
제품 개요
CSB rabbit polyclonal antibody는 인간 ERCC6 단백질을 인식하는 항체로, DNA 수선 과정 및 Cockayne syndrome 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CSB rabbit pAb |
| Alternative Names | ERCC6; CSB; DNA excision repair protein ERCC-6; ATP-dependent helicase ERCC6; Cockayne syndrome protein CSB |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Antiserum produced against synthesized peptide derived from human ERCC6 (AA range: 141–190) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
| GeneID (Human) | 2074 |
| Human Swiss-Prot No | Q03468 |
| Cellular Localization | Nucleus |
Background
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3′ splice site upstream of the ORF of the adjacent gene, piggyback-derived-3 (GeneID: 267004), activating the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [Provided by RefSeq, Mar 2016]
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