ELK Biotechnology ErbB-4 rabbit pAb
ErbB-4 단백질을 인식하는 토끼 폴리클로날 항체로 WB, IHC, IF, ELISA에 사용 가능. 인간 HER4 유래 합성 펩타이드로 면역화됨. 세포막 및 핵 내 단백질 검출에 적합하며, 다양한 종(Human, Mouse, Rat)에 반응. -20°C에서 1년 보관 가능.
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제품명
ErbB-4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB4; HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100 - 1/300 IF: 1/200 - 1/1000 ELISA: 1/20000 WB: 1/500 - 1/2000 |
| Immunogen | Synthesized peptide derived from human HER4 (AA range: 1250-1299) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 2066 |
| Human Swiss-Prot No. | Q15303 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Upon NRG1 treatment, the activated receptor is internalized. The ERBB4 intracellular domain (E4ICD) translocates to the nucleus and mitochondrion. E4ICD2 is predominantly nuclear and colocalizes with YAP1. |
Background
This gene belongs to the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine-rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphatidylinositol-3 kinase binding site, and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors, inducing various cellular responses including mitogenesis and differentiation. Proteolytic processing releases cytoplasmic and extracellular fragments. Mutations in this gene are associated with cancer. Multiple alternatively spliced variants exist, encoding different isoforms, though not all are fully characterized. (RefSeq, Jul 2008)
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