ELK Biotechnology c-Fms (phospho Tyr708) rabbit pAb
인간, 마우스, 랫트에 반응하는 c-Fms (phospho Tyr708) rabbit polyclonal antibody. Western blot과 ELISA에 적합하며, 세포막 단백질 인식. 인산화 부위 특이적 면역원으로 제작되어 신호전달 연구에 유용.
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제품명
c-Fms (phospho Tyr708) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human c-Fms (phospho Tyr708) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| Gene ID (Human) | 1436 |
| Human Swiss-Prot No | P07333 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1 (CSF1), a cytokine that controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2013)
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