
ELK Biotechnology Nectin 1 rabbit pAb
Nectin 1 rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, 세포막 접착 단백질 검출에 적합합니다. WB와 ELISA에 사용 가능하며, 높은 특이성과 안정성을 제공합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology Nectin 1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Nectin 1 rabbit pAb |
| Alternative Names | PVRL1; HVEC; PRR1; Poliovirus receptor-related protein 1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Herpesvirus Ig-like receptor; HIgR; Nectin-1; CD111 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000; ELISA: 1/10000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human PVRL1 (AA range: 81–130) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 57 kD |
| GeneID (Human) | 5818 |
| Human Swiss-Prot No | Q15223 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform Alpha: Cell membrane; Single-pass type I membrane protein; Cell junction, synapse, presynaptic cell membrane. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Gamma: Secreted. |
Background
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule belonging to the immunoglobulin superfamily, with 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. It acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and pseudorabies virus (PRV), mediating viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
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