ELK Biotechnology Crystallin-αB (phospho Ser19) rabbit pAb
Crystallin-αB (phospho Ser19) rabbit pAb는 인산화된 Ser19 부위를 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포질과 핵에 위치한 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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Crystallin-αB (phospho Ser19) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Crystallin-αB (phospho Ser19) rabbit pAb |
| Alternative Names | CRYAB; CRYA2; Alpha-crystallin B chain; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CRYAB around the phosphorylation site of Ser19. AA range: 10-59 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 24 kD |
| Gene ID (Human) | 1410 |
| Human Swiss-Prot No. | P02511 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Nucleus, Secreted, Lysosome. Translocates to the nucleus during heat shock and resides in sub-nuclear structures (SC35 speckles). Localizes at Z-bands and intercalated disks in cardiomyocytes. Can be secreted via TMED10-mediated pathway through the ERGIC compartment. |
Background
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, corresponding to acidic and basic forms, respectively. They belong to the small heat shock protein (HSP20) family and function as molecular chaperones that maintain proteins in large soluble aggregates rather than refolding them. Post-translational modifications can reduce their chaperone activity. Alpha crystallin complexes typically consist of 30–40 subunits with an alpha-A to alpha-B ratio of 3:1. Additional roles include autokinase activity and involvement in intracellular architecture. The encoded protein is known as a moonlighting protein due to its multiple mechanistic functions.
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