Thermo Fisher Scientific SCN8A Polyclonal Antibody
SCN8A 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. Nav1.6/SCN8A 내인성 수준 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human SCN8A (Accession Q9UQD0), corresponding to amino acid residues Y1038–N1088 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852518 |
Product Specific Information
Antibody detects endogenous levels of total Nav1.6/SCN8A.
Target Information
The sodium channel protein type 8 subunit alpha (Na⁺ CP type VIII alpha) is a multi-pass transmembrane protein that mediates sodium ion permeability in excitable membranes. Voltage-gated sodium channels consist of a pore-forming alpha subunit and two beta subunits (beta1 and beta2), which regulate channel expression, modulate gating, and function as cell adhesion molecules.
Type I and III alpha subunits are mainly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are abundant along axons. Sodium channels are essential for rapid signal transduction and neuronal development.
Defects in the SCN8A gene can lead to impaired growth of secondary motoneurons, progressive paralysis, and early death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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