Thermo Fisher Scientific NOTCH1 (Cleaved Val1744) Polyclonal Antibody
NOTCH1 단백질의 활성화 절편(Val1744 인접 부위)을 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 사용 가능. 인간, 생쥐, 랫트 반응성. 액상형, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NOTCH1 (Accession P46531), corresponding to amino acid residues F1744–F1773 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818381 |
Product Specific Information
Antibody detects endogenous levels of fragment of activated Notch1 resulting from cleavage adjacent to Val1744.
Target Information
The notch gene belongs to a family of epidermal growth factor (EGF)-like homeotic genes, which encode transmembrane proteins with multiple cysteine-rich EGF-like repeats in the extracellular region.
Four notch genes have been described in mammals: Notch1, Notch2, Notch3, and Notch4 (Int-3), which are involved in differentiation of the nervous system and other structures.
EGF-like proteins Delta and Serrate act as ligands for Notch1. Mature Notch proteins are heterodimeric receptors formed by cleavage of Notch pre-proteins into an extracellular subunit (NEC) and a transmembrane subunit (Ntm).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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