Thermo Fisher Scientific NOX3 Polyclonal Antibody
Thermo Fisher의 NOX3 폴리클로날 항체는 인간 및 생쥐 시료에서 NOX3 단백질 검출에 적합합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 보관용 액상 항체로 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 15 amino acid peptide near the amino terminus of human NOX3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2554640 |
Product Specific Information
PA5-38036 detects NOX3 in mouse bone marrow and human G-CSF mobilized CD34+ cells in immunofluorescence analysis.
A recommended positive control is 293 cell lysate.
NOX3 is not expected to cross-react with other NOX proteins.
Target Information
The NOX family of NADPH oxidases consists of seven transmembrane proteins that oxidize intracellular NADPH/NADH, leading to electron transport across membranes and reduction of molecular oxygen to superoxide.
NOX3 is predominantly expressed in the inner ear and is involved in the biogenesis of otoconia/otolith.
It has been suggested that NOX3 is activated by Transient Receptor Potential Vanilloid 1 (TRPV1), resulting in increased reactive oxygen species in the inner ear, which may lead to STAT1-mediated inflammation and hearing loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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