Thermo Fisher Scientific CD209a Monoclonal Antibody (LWC06), APC, eBioscience
마우스 CD209a(CIRE/DC-SIGN)에 특이적인 LWC06 단클론 항체로, APC 형광 표지되어 흐름세포분석에 적합합니다. Rat IgG2a, kappa 아이소타입이며 0.2 mg/mL 농도의 PBS 용액 형태로 제공됩니다. 면역세포 상호작용 연구용으로 사용됩니다.
- 카탈로그번호
- 17-2092-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD209a Monoclonal Antibody (LWC06), APC, eBioscience
Thermo Fisher Scientific CD209a Monoclonal Antibody (LWC06), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LWC06 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1210576 |
Additional Formats
- Unconjugated
- Biotin
- FITC
- PE
- Custom conjugation available
Product Specific Information
The LWC06 antibody was generated by immunization with the recombinant extracellular region of mouse CIRE/DC-SIGN (CD209).
CIRE/DC-SIGN is expressed on CD8α⁻ dendritic cells and plasmacytoid predendritic cells and is homologous to human DC-SIGN.
Human DC-SIGN binds HIV gp120 independently of CD4.
CIRE/DC-SIGN is a 33 kDa type II transmembrane C-type lectin with a carbohydrate recognition domain (CRD) that binds mannose and other carbohydrates in a calcium-dependent manner.
It may mediate T-dendritic cell interactions via ICAM family binding.
Expression varies by dendritic cell activation state and is downregulated in GM-CSF–supplemented cultures.
The LWC06 antibody does not cross-react with SIGNR1–SIGNR4.
CD209 protein is sensitive to collagenase treatment.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of transfected cell lines; recommended ≤0.25 µg per test (100 µL final volume).
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
This gene encodes a transmembrane receptor known as DC-SIGN, expressed on dendritic cells and macrophages.
It recognizes a wide range of pathogens and participates in innate immunity.
The protein consists of three domains: transmembrane, neck (tandem-repeat), and C-type lectin carbohydrate recognition domain.
The extracellular region acts as both a pathogen recognition and cell adhesion receptor.
Neck domain oligomerization enhances multivalent ligand binding.
Variations in neck repeats affect ligand binding.
Closely related to L-SIGN (GeneID 10332), differing in ligand-binding and tissue distribution.
Alternative splicing yields multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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