Thermo Fisher Scientific Phospho-BCL9L (Ser21 ) Polyclonal Antibody

Thermo Fisher Scientific Phospho-BCL9L (Ser21) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of BCL9L only when phosphorylated at Ser21.

Target Information

Bcl9L, a homolog of Bcl9, was initially identified through bioinformatics screening. It is expressed in fetal brain, adult lung, eye, and prostate, as well as in several tumor types including pancreatic and prostate cancers.
Bcl9L interacts with beta-catenin, a target of the Wnt signaling pathway, and is required for enhanced beta-catenin–TCF-mediated transcription in colorectal tumor cells, possibly by translocating beta-catenin to the nucleus.
Studies indicate that Bcl9L expression correlates with high nuclear grade cancer phenotype and ErbB2/HER-2 expression in breast cancers, suggesting its activity may occur in other cancer types.
Bcl9L is also critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas, associated with tumor invasion, metastasis, and therapy resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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