Thermo Fisher Scientific Tau Chimeric Recombinant Rabbit Monoclonal Antibody (Tau-5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Specificity: This antibody binds to sequence 210–241 of tau protein.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. Its primary function is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both structures.

Axonal polarity is influenced by TAU/MAPT localization within the neuronal cell body. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms may play a role in stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which are central to neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs Tau’s microtubule-binding function, leading to microtubule destabilization and neuronal degeneration.

Numerous serine/threonine kinases phosphorylate Tau, including GSK-3β, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5), and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions in various central nervous system disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.