Thermo Fisher Scientific B3GNT1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human B3GNT1. Recombinant protein control fragment (Product #RP-89938). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:B3GNT1,uniProtId:O43505-1,ncbiNodeId:9606,antigenRange:40-183,antigenLength:415,antigenImageFileName:PA5-53307_B3GNT1_O43505-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53307_B3GNT1_O43505-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638421

Product Specific Information

Immunogen sequence: EEQDQYFEFF PPSPRSVDQV KAQLRTALAS GGVLDASGDY RVYRGLLKTT MDPNDVILAT HASVDNLLHL SGLLERWEGP LSVSVFAATK EEAQLATVLA YALSSHCPDM RARVAMHLVC PSRYEAAVPD PREPGEFALL RSCQ

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.

Target Information

Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha- dystroglycan (DAG1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.