Thermo Fisher Scientific PAX2 (Renal Cell and Ovarian Carcinoma Marker) Monoclonal Antibody (PAX2/1105)
PAX2 단백질을 인식하는 마우스 단클론 항체로, 신장세포암 및 난소암 표지에 활용됩니다. 인체 시료에 반응하며 IHC(P) 및 IHC(PFA)에 적합합니다. Protein A/G로 정제된 액상 항체로, 보존제 없이 PBS(pH 7.4)에 저장됩니다. 연구용 전용 제품입니다.
- 카탈로그번호
- 5076-MSM2-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PAX2/1105 |
| Immunogen | Recombinant fragment (around aa 223–354) of human PAX2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The PAX gene family encodes transcription factors active during early embryonic development. These genes contain a paired box DNA-binding domain and regulate genetic programs essential for tissue differentiation.
PAX2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures derived from mesenchyme. Its expression decreases as renal tubular epithelium matures but persists in undifferentiated epithelium of Wilms’ tumors, correlating with proliferation of poorly differentiated epithelial cells. WT1 tumor suppressor expression coincides with down-regulation of PAX2, suggesting WT1 may repress PAX2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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