Thermo Fisher Scientific TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)
TP63 단백질을 인식하는 Recombinant Rabbit Monoclonal Antibody. Western blot 및 Immunocytochemistry에 최적화. Human 시료에 반응하며 Monkey, Mouse, Rat, Bovine에도 예측 반응. Protein A 정제, 0.5 mg/mL 농도, PBS buffer에 0.09% sodium azide 포함.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10H7L17 |
| Immunogen | Protein corresponding to human TP63 [aa360–aa500] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809251 |
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, Rat, and Bovine.
Target Information
TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. Isoforms contain varying transactivation and inhibitory domains, showing isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may cooperate with TP73/p73 for p53/TP53-dependent apoptosis in response to genotoxic stress and oncogene activation. It is involved in Notch signaling via JAG1 and JAG2 induction and plays a role in epithelial morphogenesis regulation. The ratio of DeltaN-type and TA-type isoforms influences epithelial stem cell maintenance and stratification initiation. TP63 is required for limb formation from the apical ectodermal ridge and can activate p21 promoter transcription. Mutations in TP63 are associated with several syndromes, including acro-dermato-ungual-lacrimal-tooth syndrome, ectodermal dysplasia variants, and orofacial cleft 8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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