Thermo Fisher Scientific TMEM119 Recombinant Rabbit Monoclonal Antibody (HL2415)
Recombinant rabbit monoclonal antibody targeting TMEM119 (clone HL2415). Validated for IHC (P) in mouse and rat. High purity via Protein A, unconjugated form, supplied at 1 mg/mL. Ideal for microglia marker studies and neuroinflammation research.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2415 |
| Immunogen | Recombinant fragment of mouse TMEM119 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093842 |
Target Information
Tmem119 encodes a single-pass type I transmembrane protein that interacts with multiple micro-RNAs and transcription factors such as SMAD1, SMAD5, and RUNX2. It serves as a reliable surface marker for microglia, distinguishing them from infiltrating macrophages. Microglial cells are brain-resident phagocytes involved in debris clearance and dendritic pruning, exhibiting neuroprotective and neurotoxic functions depending on environmental cues.
Reactive microglia co-express Iba1 and, under pathological conditions, secrete Cq1, IL-1a, and TNF when stimulated with LPS, contributing to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Multiple Sclerosis. Outside the neural system, Tmem119 may play a role in osteoblast differentiation and ossification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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