Thermo Fisher Scientific CXCR4 Recombinant Rabbit Monoclonal Antibody (HL2424)
CXCR4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, HEK293 세포에서 발현되었습니다. 단백질 A로 정제된 액상 형태로 제공되며, 보존제는 포함되어 있지 않습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2424 |
| Immunogen | Synthetic peptide of human CXCR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092925 |
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven transmembrane domains, functioning as a co-receptor for X4 HIV-1 entry into CD4+ cells. It also serves as a co-receptor for HIV-2 binding to CD4 via gp120 and promotes Env-mediated viral fusion. CXCR4 acts as a receptor for the C-X-C chemokine CXCL12/SDF-1, mediating intracellular calcium increase and MAPK1/MAPK3 activation. It is involved in hematopoiesis, cardiac ventricular septum formation, and vascularization of the gastrointestinal tract. In the CNS, CXCR4 mediates hippocampal neuron survival and cerebellar development. CXCR4 also binds bacterial LPS, mediating LPS-induced inflammatory responses including TNF secretion by monocytes. Antibodies against CXCR4 can block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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