Thermo Fisher Scientific Integrin beta 7 Monoclonal Antibody (1B4A8)
Integrin beta 7 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 고순도 Protein G 정제, PBS 버퍼에 0.05% sodium azide 포함, 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B4A8 |
| Immunogen | Purified recombinant fragment of human ITGB7 (AA: 20–174) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091063 |
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1, and fibronectin, while the ligand of HML-1 is E-cadherin (CD324).
Integrin beta 7 plays an important role in leukocyte adhesion to endothelial cells, promoting transmigration of leukocytes to extravascular spaces during inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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