Thermo Fisher Scientific IGF2BP3 Polyclonal Antibody
Thermo Fisher Scientific의 IGF2BP3 Polyclonal Antibody는 인간 시료에 반응하며, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. Rabbit IgG 기반으로 항원 친화 크로마토그래피로 정제되었으며, 고농도 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 289–568 of Human IMP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.56 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547872 |
Product Specific Information
- Recommended positive controls: PC-3, SK-N-SH
- Predicted reactivity: Mouse (98%), Zebrafish (80%), Xenopus laevis (83%), Chicken (82%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, belongs to the IGF-II mRNA-binding protein family. It is expressed during embryogenesis and in certain malignancies. IMP-3 is found in malignant melanoma but not in benign nevi, even with dysplastic features. It is more highly expressed in melanomas than in Spitz nevi and in metastatic melanomas compared to thin melanomas. IMP-3 may be involved in melanoma progression and regulation of tumor behavior.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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