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Thermo Fisher Scientific Alpha-Smooth Muscle Actin Monoclonal Antibody (1A4), Alexa Fluor 700

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Alpha-Smooth Muscle Actin(α-SMA)을 인식하는 1A4 단클론 항체로, Alexa Fluor 700으로 표지되어 있습니다. 사람, 마우스, 랫트 시료에 반응하며 IHC(P)에서 1 µg/mL로 사용 가능합니다. 평활근세포 및 근섬유모세포 표지에 유용하며 연구용으로만 사용됩니다.

카탈로그번호: 56976082
브랜드: Thermo Fisher Scientific
카테고리: Monoclonal Antibodies
판매단위: pk

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마지막 업데이트 2025. 08. 01. 오후 11:31

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Thermo Fisher Scientific 56976082 Alpha-Smooth Muscle Actin Monoclonal Antibody (1A4), Alexa Fluor 700 100 ug pk판매 단위 pk ·

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818,200원VAT 포함 900,020원

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Thermo Fisher Scientific · Thermo Fisher Scientific Alpha-Smooth Muscle Actin Monoclonal Antibody (1A4), Alexa Fluor 700

Applications and Tested Dilution

Application	Tested Dilution
Immunohistochemistry (Paraffin) (IHC (P))	1 µg/mL

Product Specifications

항목	내용
Species Reactivity	Human
Host / Isotype	Mouse / IgG2a, kappa
Class	Monoclonal
Type	Antibody
Clone	1A4
Conjugate	Alexa Fluor™ 700
Excitation / Emission Max	696 / 719 nm
Form	Liquid
Concentration	0.2 mg/mL
Purification	Affinity chromatography
Storage Buffer	PBS, pH 7.2, with 0.5% BSA, 10% proprietary stabilizer
Contains	0.05% sodium azide
Storage Conditions	4°C, store in dark, DO NOT FREEZE
Shipping Conditions	Wet ice

Additional Formats

Unconjugated (Cat. MA1-06110)
Alexa Fluor 420 (Cat. 758-9760-82)
Alexa Fluor 514 (Cat. 753-9760-82)
Alexa Fluor Plus 594 (Cat. 755-9760-82)
Alexa Fluor Plus 750 (Cat. 757-9760-82)
Custom conjugation available upon request

Product Specific Information

The monoclonal antibody 1A4 recognizes human, mouse, and rat alpha-smooth muscle actin (α-SMA), a 42 kDa protein that is a major component of the cytoskeletal structural network. This antibody specifically detects the alpha form of muscle actin expressed by smooth muscle cells of blood vessels, myofibroblasts, and myoepithelial cells. It is also found in the parenchyma and stroma of various tissues.
Alpha-smooth muscle actin is useful for identifying leiomyomas, leiomyosarcomas, and pleomorphic adenomas and serves as a prognostic marker for basal cell carcinoma.

Applications Reported:

Immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections
Immunocytochemistry

Applications Tested:
This antibody has been validated for IHC using high pH antigen retrieval and can be used at 1 µg/mL. Optimal dilution should be determined experimentally.

Handling Note:
Centrifuge the conjugate solution briefly before use and use only the supernatant to minimize nonspecific background caused by aggregates.

Target Information

Smooth Muscle Actin belongs to the actin family of highly conserved proteins involved in cell motility, structure, and integrity. Alpha actin is a major component of the contractile apparatus, while beta and gamma actins regulate cell motility.
Smooth muscle actin is abundant in vascular and visceral smooth muscle cells and is also observed in fibroblastic stress fibers during wound healing and fibrocontractive diseases.
Defects in the smooth muscle actin gene are associated with familial thoracic aortic aneurysm type 6. Multiple alternatively spliced variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.