Thermo Fisher Scientific Desmocollin 2 Polyclonal Antibody

Thermo Fisher Scientific Desmocollin 2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
IDENTGSIKV FRSLDREAET IKNGIYNITV LASDQGGRTC TGTLGIILQD VNDNSPFIPK KTVIICKPTM SSAEIVAVDP DEPIHGPPFD FSLESSTSEV QRMWRLKAIN DTAARLSYQN DPPFGSYVVP ITVRDRLGMS SVTSLDVTLC DCITENDCTH RVDPRIGGGG V

Positive Samples: A-431, Raji, LO2, BT-474, HT-29
Cellular Location: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome

Target Information

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-87712_Desmocollin_2_Q02487-1_Rabbit_PDP.jpeg, PA5-87712_Desmocollin_2_Q02487-1_Rabbit.svg)