Thermo Fisher Scientific Desmocollin 2 Polyclonal Antibody
Human Desmocollin 2 단백질을 표적으로 하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer에 저장. 세포 접합부 및 막 단백질 연구에 활용 가능.
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Thermo Fisher Scientific Desmocollin 2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 520–690 of human DSC2 (NP_0777401) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804361 |
Product Specific Information
Immunogen sequence:
IDENTGSIKV FRSLDREAET IKNGIYNITV LASDQGGRTC TGTLGIILQD VNDNSPFIPK KTVIICKPTM SSAEIVAVDP DEPIHGPPFD FSLESSTSEV QRMWRLKAIN DTAARLSYQN DPPFGSYVVP ITVRDRLGMS SVTSLDVTLC DCITENDCTH RVDPRIGGGG V
Positive Samples: A-431, Raji, LO2, BT-474, HT-29
Cellular Location: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome
Target Information
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-87712_Desmocollin_2_Q02487-1_Rabbit_PDP.jpeg, PA5-87712_Desmocollin_2_Q02487-1_Rabbit.svg)
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