Thermo Fisher Scientific Fbx32 Polyclonal Antibody
Fbx32 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등에 사용 가능. Mouse와 Rat 시료에 반응하며, muscle atrophy 연구에 적합. Affinity chromatography로 정제된 고순도 항체.
- 카탈로그번호
- ATR-101AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 240–280 on Atr1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid motif known as the F-box. F-box proteins form one of the four subunits of the ubiquitin protein ligase complex (SCFs), which function in phosphorylation-dependent ubiquitination.
The F-box proteins are divided into three classes:
- Fbws: containing WD-40 domains
- Fbls: containing leucine-rich repeats
- Fbxs: containing various protein–protein interaction modules or no recognizable motifs
The encoded protein belongs to the Fbxs class and contains an F-box domain. It is highly expressed during muscle atrophy, and mice deficient in this gene are resistant to atrophy. Therefore, this protein is a potential drug target for the treatment of muscle atrophy. Alternative splicing results in two transcript variants encoding isoforms of different sizes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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