Thermo Fisher Scientific Fbx32 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes a member of the F-box protein family, characterized by an approximately 40 amino acid motif known as the F-box. F-box proteins form one of the four subunits of the ubiquitin protein ligase complex (SCFs), which function in phosphorylation-dependent ubiquitination.
The F-box proteins are divided into three classes:

• Fbws: containing WD-40 domains
• Fbls: containing leucine-rich repeats
• Fbxs: containing various protein–protein interaction modules or no recognizable motifs

The encoded protein belongs to the Fbxs class and contains an F-box domain. It is highly expressed during muscle atrophy, and mice deficient in this gene are resistant to atrophy. Therefore, this protein is a potential drug target for the treatment of muscle atrophy. Alternative splicing results in two transcript variants encoding isoforms of different sizes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.