Thermo Fisher Scientific p53 (Tumor Suppressor Protein Monoclonal Antibody (PCRP-TP53-2A10)

Applications and Tested Dilution

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. Upon activation, p53 induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest.

Structurally, p53 includes:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerization domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is critical for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 plays a vital role in preventing proliferation of damaged cells and functions as an anticancer factor. It is also linked to aging, oxidative stress, and learning/memory processes.

Mutations in the TP53 gene are common in human cancers and can lead to loss of tumor suppressor activity. Both somatic and germline mutations (e.g., in Li-Fraumeni syndrome) have been identified.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.