Thermo Fisher Scientific STAT5 alpha/beta Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

View 1 publication 1 publication

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic Peptide derived from an internal region of human STAT5.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_325617

Product Specific Information

OPA1-03010 detects signal transducer and activator of transcription 5 a/b (STAT5) from human, mouse, and hamster tissues and cells. Rat tissues are expected to react based on sequence homology. This antibody is specific for STAT5 and does not cross-react with any other STATs or related proteins. OPA1-03010 has been successfully used in western blot procedures. By western blot, this antibody detects an ~92 and ~85 kDa protein representing STAT5a and STAT5b, respectively, from CTLL cell lysate. OPA1-03010 was raised against a synthetic peptide derived from an internal region of human STAT5. The sequence of the immunogen is identical in rat.

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.