Thermo Fisher Scientific INSIG1 Polyclonal Antibody
INSIG1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. 인간과 랫드 시료 반응성이 있으며, 합성 펩타이드(aa 200–C-terminus)를 면역원으로 사용했습니다. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human INSIG1 (NP_005533.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.56 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855273 |
Product Specific Information
Immunogen sequence:
LWWTFDRSRS GLGLGITIAF LATLITQFLV YNGVYQYTSP DFLYIRSWLP CIFFSGGVTV GNIGRQLAMG VPEKPHSD
Target Information
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathways. This gene is insulin-induced and encodes an endoplasmic reticulum (ER) membrane protein critical for regulating intracellular cholesterol levels. The INSIG1 protein binds to sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, essential for sterol-mediated trafficking of these proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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