Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting Synaptotagmin 1 for detection in WB, ICC/IF, and ELISA. Reacts with human, mouse, and rat. Affinity purified, liquid form, stored at -20°C. Suitable for research on synaptic vesicle function and neurotransmitter rel...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 84–157 of human SYT1 (NP_005630.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.46 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804245 |
Product Specific Information
Immunogen sequence:
LFKKKNKKKG KEKGGKNAIN MKDVKDLGKT MKDQALKDDD AETGLTDGEE KEEPKEEEKL GKLQYSLDYD FQNN
Positive Samples: SW620, A673
Cellular Location: Cytoplasm, cytoplasmic vesicle, single-pass membrane protein, chromaffin granule membrane, secretory vesicle, synaptic vesicle membrane
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the central nervous system. It functions as a Ca²⁺ sensor regulating exocytosis and neurotransmitter release. Synaptotagmin’s Ca²⁺-mediated binding to SNAP25 is essential for Ca²⁺-dependent membrane fusion. Specific residues in the C2B binding domain influence endocytic rate and vesicle size. It also binds acidic phospholipids requiring both an acidic head group and diacyl backbone. Ca²⁺-dependent interactions occur with receptors for activated protein kinase C, while Ca²⁺-independent binding occurs with neurexins, syntaxin, and AP2. Dysfunctions in Synaptotagmin 1 are linked to food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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