Thermo Fisher Scientific FGF2 Polyclonal Antibody, Biotin
인간 FGF2 단백질을 인식하는 바이오틴 결합 폴리클로날 항체로, Western blot과 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS 용액 형태로 제공되며, 단기 4°C·장기 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific FGF2 Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL |
| ELISA | 0.15–0.3 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human FGF2 protein (UniProt ID: P09038-4, range: 1–288) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_780596 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FGF2 (fibroblast growth factor basic, FGFb) is a member of the fibroblast growth factor family that interacts with high-affinity transmembrane receptors to regulate cell proliferation and neovascularization.
It exists as five isoforms with distinct intracellular localizations and functions:
- The 18 kDa isoform is cytosolic and acts through cell surface receptors.
- The 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of transmembrane receptor pathways.
In humans, the FGF2 gene is located on chromosome 4q and plays roles in limb and nervous system development, wound healing, and tumor growth.
FGF2 mRNA contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, producing five isoforms with distinct properties.
CUG-initiated isoforms are nuclear (intracrine signaling), while AUG-initiated forms are cytosolic (paracrine and autocrine signaling).
FGF2 dysfunction has been associated with Kaposi Sarcoma and corneal neovascularization.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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