Thermo Fisher Scientific USP5/IsoT Polyclonal Antibody
USP5/IsoT 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 USP5의 75–125번 잔기 영역을 면역원으로 제작되었으며, 액상 형태로 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 75 and 125 of Human ubiquitin specific peptidase 5 (isopeptidase T) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.
It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity.
Knock-down of USP5 causes accumulation of p53/TP53 and increases its transcriptional activity because unanchored polyubiquitin competes with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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