Thermo Fisher Scientific Phospho-ABL1/ABL2 (Tyr393, Tyr439) Polyclonal Antibody
ABL1/ABL2 인산화형(Tyr393, Tyr439)을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합. 인간 및 생쥐 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. 연구용으로만 사용.
- 카탈로그번호
- PA537468
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-ABL1/ABL2 (Tyr393, Tyr439) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 393/439 (D-T-Y(p)-T-A) derived from Human ABL1/2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554077 |
Product Specific Information
- Suggested positive control for Western blot: HL60 cells
- Suggested positive control for IHC: human breast carcinoma
- Suggested positive control for ICC/IF: HeLa cells
Target Information
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has tyrosine kinase activity and an SH2 domain.
The Abl oncogene is implicated in several human leukemias, including:
- 90–95% of chronic myelocytic leukemia (CML)
- 20–25% of adult acute lymphoblastic leukemia (ALL)
- 2–5% of pediatric ALL
In these leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome, leading to a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.