Thermo Fisher Scientific CD103 Polyclonal Antibody
Human CD103/Integrin alpha E 특이적 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 보존제가 없는 액상 형태이며, 고순도 Protein A 및 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the center region of Human CD103/Integrin alpha E/ITGAE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788026 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CD103/Integrin alpha E/ITGAE.
Target Information
CD103 (ITGAE, Integrin alpha E) is expressed on mucosa-associated T lymphocytes and activated cells, as well as a subset of TGF beta-1 cells. It includes a 150 kDa alpha chain and a 120 kDa beta chain. CD103 is expressed by 0.5–2% of resting lymphocytes in peripheral blood and lymphoid organs. It stains a few bone marrow cells and rarely peripheral blood lymphocytes.
CD103 belongs to the integrin family, composed of heterodimeric integral membrane proteins with alpha and beta chains. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, forming disulfide-linked heavy and light chains.
When combined with beta 7 integrin, CD103 forms the E-cadherin binding integrin known as human mucosal lymphocyte-1 antigen. It is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL) and may play roles in adhesion and activation.
Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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