Thermo Fisher Scientific Phospho-JNK1 (Thr183) Polyclonal Antibody
Human JNK1의 Thr183 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Dot blot에서 1:500 희석으로 검증됨. MAPK8 신호전달 연구 및 스트레스 반응, 인슐린 저항성 관련 연구에 적합. Protein A 및 항원 친화 크로마토그래피로 정제됨.
- 판매단위
- pk
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Applications
- Dot blot (DB): Tested dilution 1:500
- Publications: Refer to references component
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T183 of human MAPK8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984361 |
Product Specific Information
This antibody is predicted to react with mouse, rat, and Xenopus based on sequence homology.
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is a crucial mediator of insulin resistance and obesity and belongs to the MAPK superfamily of stress-activated protein kinases.
MAPKs are serine-threonine kinases activated by various extracellular stimuli, mediating signal transduction from the cell surface to the nucleus.
JNK is involved in cellular processes such as proliferation, differentiation, transcription regulation, and development. JNK pathways are activated by stress and inflammatory signals.
JNK exists as ten isoforms due to differential mRNA splicing, with JNK1 and JNK2 being predominant.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-12867_JNK1_P45983-1_Rabbit.svg, PA5-12867_JNK1_P45983-1_Rabbit_PDP.jpeg)
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