Thermo Fisher Scientific TNNI3 Monoclonal Antibody (OTI4E5), TrueMAB
Cardiac Troponin I 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB 및 ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. 인간 및 개 시료 반응성, 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2500–1:5000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E5 |
| Immunogen | Full length human recombinant protein of human TNNI3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cardiac Troponin I (TNNI3) is an integral inhibitory protein in cardiac muscle, forming a complex with troponin C (TnC) and troponin T (TnT). TnT binds to tropomyosin to form a troponin-tropomyosin complex anchored by TnI binding to actin within thin filaments. Calcium binding to TnC causes structural changes that release TnI from actin, enabling myosin attachment and muscle contraction. Blood levels of TnI and TnT serve as diagnostic indicators for cardiac muscle damage and help differentiate between angina and myocardial infarction. Mutations in the TNNI3 gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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