Thermo Fisher Scientific NARF Monoclonal Antibody (7D9)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MKCEHCTRKE CSKKTKTDDQ ENVSADAPSP AQENGEKGEF HKLADAKIFL SDCLACDSCM TAEEGVQLSQ QNAKDFFRVL NLNKKCDTSK HKVLVVSVCP

Target Information

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment; however, it also plays a role in protein-protein interactions.
The only nuclear proteins known to be prenylated in mammalian cells are prelamin A and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This modified cysteine is removed when prelamin A is processed into mature lamin A.
The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain and may be part of a prelamin A endoprotease complex. It is located in the nucleus and partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases.
Alternatively spliced transcript variants encoding different isoforms have been identified, including one generated by RNA editing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.