Thermo Fisher Scientific EPCR Monoclonal Antibody (LMR-42)

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

-

Flow Cytometry (Flow)

1:20

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

LMR-42

Immunogen

Proprietary immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant with 0.7% BSA

Contains

0.1% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_2172429

Product Specific Information

LMR-42 detects an outer-surface epitope of a 55 kDa plasma membrane protein overexpressed in several human non-Pgpmultidrug-resistant (MDR) tumor cell lines. Expression cloning revealed that the LMR-42 antigen is identical to the human endothelial cell protein Creceptor (EPCR). Protein C is the zymogen of the key anticoagulant enzyme, activated protein C (APC).

Target Information

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.