Thermo Fisher Scientific CD11a Polyclonal Antibody
CD11a 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 면역조직화학(IHC)에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/50% glycerol 용액에 보관되며, -20°C에서 안정적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ITGAL (Accession P20701), corresponding to amino acid residues K93–G143 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900075 |
Product Specific Information
This antibody detects endogenous levels of total ITGAL.
Target Information
CD11a (LFA-1 alpha, ITGAL) forms the LFA-1 complex together with CD18 (alphaLbeta2 integrin). It plays a key role in leukocyte adhesion by interacting with ICAM-1, -2, and -3, and is involved in lymphocyte costimulatory signaling. CD11a exists in low- and high-affinity conformations depending on cell activation state. It regulates immune cell interactions, differentiation, and T-cell effector functions. Targeting CD11a with antibodies or small molecules has therapeutic potential for inflammatory diseases. For example, the humanized anti-CD11a antibody Efalizumab (Raptiva) is used to inhibit T-cell migration, while simvastatin binding to CD11a modulates immune activity. Two transcript variants encoding different isoforms of CD11a are known. Dysfunction of CD11a is associated with benign cephalic histiocytosis and leukocyte adhesion deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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