Thermo Fisher Scientific JAK1 Polyclonal Antibody
JAK1 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫 등 다양한 종에 반응. WB 및 ICC/IF에 사용 가능하며, 고순도 Affinity chromatography로 정제됨. 액상 형태로 PBS 및 50% glycerol에 보관, 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK1 (Accession P23458), corresponding to amino acid residues T1100–E1150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900078 |
Product Specific Information
Antibody detects endogenous levels of total JAK1.
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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