Thermo Fisher Scientific CD18 Polyclonal Antibody
CD18 단백질을 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도의 친화 크로마토그래피 정제 제품입니다. 세포 부착 및 면역 신호 연구용으로 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ITGB2 (Accession P05107), corresponding to amino acid residues P66–N116. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900076 |
Product Specific Information
This antibody detects endogenous levels of total ITGB2/CD18.
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11 molecules (CD11a–d) to create β2 integrins, including:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins mediate cell adhesion and signaling, essential for leukocyte migration and intercellular interactions. Deficiency or malfunction of CD18 leads to leukocyte adhesion deficiency type I (LAD1) and can cause immune dysfunction and skin disorders. CD18 is also a target of Mannheimia haemolytica leukotoxin, mediating cytolysis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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