Thermo Fisher Scientific ATF1 Polyclonal Antibody
ATF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 액상 형태로 제공되며 4°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human Activating Transcription Factor 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The ATF1 gene encodes an activating transcription factor belonging to the ATF subfamily and bZIP (basic-region leucine zipper) family. It regulates the expression of downstream target genes involved in growth, survival, and cellular activities.
This protein is phosphorylated at serine 63 in its kinase-inducible domain by several serine/threonine kinases including cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase, and cyclin-dependent kinase 3 (cdk-3).
Phosphorylation enhances its transactivation and transcriptional activities, promoting cell transformation.
Fusion of this gene with FUS (chromosome 16) or EWSR1 (chromosome 22) by translocation produces chimeric proteins associated with angiomatoid fibrous histiocytoma and clear cell sarcoma.
A pseudogene is located on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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