Thermo Fisher Scientific ZRANB3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

ZRANB3 is a DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333).
It is recruited to sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634).
In addition to endonuclease activity, it also catalyzes fork regression via annealing helicase activity to prevent disintegration of the replication fork and formation of double-strand breaks (PubMed:22705370, PubMed:22704558).
[Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.