Thermo Fisher Scientific AQP2 Polyclonal Antibody
AQP2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 IHC(Paraffin) 실험에 적합. 사람, 생쥐, 랫트 반응성. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human AQP2 (aa 100–150) conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: AQP2.
Target Information
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct.
Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans.
Vasopressin induces cAMP increase, leading to phosphorylation of AQP2 at serine-256 and translocation to the apical membrane of principal cells.
Serine-261 has been identified as a novel phosphorylation site, with phosphorylated S261 levels decreasing upon vasopressin treatment, suggesting its role in vasopressin-dependent AQP2 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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