Thermo Fisher Scientific PKN2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

PKN2 (PRK2), a close relative of PKCs, is a regulator of mitosis and cytokinesis exit. It plays a role in regulating cell cycle progression, actin cytoskeleton assembly, cell migration, adhesion, tumor invasion, and transcription activation signaling.
Phosphorylates CTTN in hyaluronan-induced astrocytes, reducing its association with filamentous actin. Also phosphorylates HDAC5, impairing HDAC5 import.
Acts as a direct RhoA target required for maturation of primordial junctions into apical junctions in bronchial epithelial cells. It is essential for G2/M phase progression and cytokinesis abscission in an ECT2-dependent manner.
Stimulates FYN kinase activity necessary for cell-cell adhesion during keratinocyte differentiation. Regulates epithelial bladder cell migration and tumor invasion. Inhibits Akt pro-survival kinase activity and mediates Rho protein-induced transcriptional activation via SRF.
Phosphorylates HCV NS5B, stimulating HCV RNA replication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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