Thermo Fisher Scientific IFN gamma Monoclonal Antibody (4S.B3), FITC, eBioscience
인간 IFN-γ를 인식하는 단클론 항체로, FITC로 표지되어 있습니다. Flow cytometry용으로 최적화되어 있으며, 5 µL/test로 사용 가능합니다. 면역조절 연구 및 세포 내 염색에 적합합니다. 4°C에서 어둡게 보관하며 동결 금지.
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IFN gamma Monoclonal Antibody (4S.B3), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | View 98 publications |
| ELISA | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4S.B3 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11043263 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 660
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395, 496, 615, 661, 737, 805
- Brilliant Violet 650
- eFluor 450, 506, 660
- PE, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
Description:
The 4S.B3 monoclonal antibody reacts with interferon-gamma (IFN gamma). Human IFN gamma is a 17 kDa cytokine produced by activated T and NK cells with antiviral and antiparasitic functions. It acts synergistically with cytokines such as TNF alpha to inhibit proliferation of normal and transformed cells and exerts immunomodulatory effects on multiple cell types expressing IFN gamma receptors. Glycosylation does not affect its biological activity.
Applications Reported:
Reported for use in intracellular staining for flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by intracellular flow cytometric analysis of activated human cells. Recommended usage: 5 µL (0.5 µg) per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test.
Fluorescence Properties:
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Interferon gamma (IFN-γ, Type II interferon) is a macrophage activation factor produced primarily by T-lymphocytes and NK cells in response to antigens and cytokines. It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits. IFN-γ exhibits antiviral and antiproliferative activity, induces MHC class I and II expression, and activates macrophages.
Human IFN-γ shows high species specificity and does not cross-react with mouse IFN-γ.
Its biological function involves the JAK-STAT signaling pathway upon receptor binding.
Mutations in the IFN-γ gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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