Thermo Fisher Scientific Human SLUG Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the center of human Slug.
PEP-0420 can be used as a blocking peptide with polyclonal antibody PA5-20290.

Target Information

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug binds E-box regions of promoters and represses transcription of genes such as E-cadherin and Claudin-1. Its expression in breast, esophageal, and colorectal carcinomas has been correlated with poor prognosis. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.