Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI2F11), TrueMAB
Human TIM-3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 Flow cytometry에 적합함. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. PBS/BSA/glycerol buffer에 보관하며 연구용으로만 사용 가능.
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI2F11), TrueMAB
Applications
- Western Blot (WB): 1:2,000
- Flow Cytometry (Flow): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F11 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
It is involved in macrophage activation and induction of autoimmune diseases. TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance.
Pathological significance has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and TIM3 enhances the severity of EAE in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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