Thermo Fisher Scientific ASCL1 Polyclonal Antibody
ASCL1 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. 인간, 마우스, 랫트 반응성. Western blot에 적합하며 고순도 (>95%)로 SDS-PAGE 검증. 신경계 발달 및 신경내분비 종양 연구용으로 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 140–190 of Human ASCL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2803400 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early development of the nervous system. Expressed in fetal brain, ASCL1 is essential for proper development and survival of subsets of autonomic neurons. Interaction with MEF-2A may regulate gene expression critical for neuronal circuit formation. High ASCL1 expression in neuroendocrine tumors such as medullary thyroid cancer and small cell lung cancer provides a useful marker for cancers with neuroendocrine features. The ASCL1 gene maps to human chromosome 12 and contains a trinucleotide repeat region, making it a candidate for inherited disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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