Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser102) Polyclonal Antibody
인산화된 Estrogen Receptor α(Ser102)를 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 생쥐, 랫트 반응성. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer에 보존. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of Serine102 (L-N-S(p)-V-S) derived from Human Estrogen Receptor-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554175 |
Product Specific Information
- Suggested positive control for Western blot: HUVEC cells
- Suggested positive control for IHC: Human breast carcinoma
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces at least four estrogen receptor-alpha isoforms (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are widely expressed and are critical for sexual development, reproductive function, bone health, and are implicated in diseases such as breast and endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(원본 항원 구조 이미지 및 PDP 이미지 포함)
- PA5-37567_Estrogen_Receptor_alpha_P03372-1_Rabbit.svg
- PA5-37567_Estrogen_Receptor_alpha_P03372-1_Rabbit_PDP.jpeg
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