Thermo Fisher Scientific Axl Monoclonal Antibody (DS7HAXL), PE-Cyanine7, eBioscience
인간 Axl 단백질을 인식하는 DS7HAXL 단클론 항체로, PE-Cyanine7으로 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 고순도 친화 크로마토그래피 정제, 광민감 염료 사용으로 암 및 면역 연구에 활용됩니다. 4°C 암소 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 5 µL (0.06 µg)/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DS7HAXL |
| Conjugate | PE-Cyanine7 |
| Excitation/Emission Max | 569/780 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723959 |
Additional Formats:
Product Specific Information
The DS7HAXL monoclonal antibody recognizes human Axl, a member of the TAM family of tyrosine kinase receptors (including MerTK and Tyro3). It is suitable for flow cytometry on both native and paraformaldehyde-fixed cells and can also stain formalin-fixed, paraffin-embedded tissues for IHC analysis.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-diluted and tested by flow cytometry on normal human peripheral blood cells
- Recommended use: 5 µL (0.06 µg) per test (in 100 µL final volume)
- Applicable cell count: 10⁵–10⁸ cells/test
Light Sensitivity:
This tandem dye is sensitive to photo-induced oxidation. Protect vials and stained samples from light.
Fixation:
Samples can be stored in IC Fixation Buffer (Product #00-8222) or 1-step Fix/Lyse Solution (Product #00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency.
Optical Properties:
Excitation: 488–561 nm
Emission: 775 nm
Compatible Lasers: Blue, Green, Yellow-Green
Target Information
AXL is a receptor tyrosine kinase associated with chronic myelogenous leukemia, colon cancer, and melanoma. It transduces extracellular signals by binding growth factors such as GAS6, promoting cell proliferation. TAM receptors (Axl, MerTK, Tyro3) are also involved in phagocytosis of apoptotic cells. Deficiency of TAM receptors in mice leads to autoimmune-like phenotypes similar to systemic lupus erythematosus.
Axl may act as an entry receptor for filoviruses and is used to identify Siglec 6+/Axl+ dendritic cell subpopulations. Expression of Axl can be upregulated by TLR ligands (e.g., LPS, poly I:C). Soluble Axl is generated by proteolytic cleavage of the membrane form; increased plasma levels may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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