Thermo Fisher Scientific CD357 (AITR/GITR) Monoclonal Antibody (110416)
CD357 (AITR/GITR) 단클론 항체로 인간 시료에 반응하며, Western blot, Flow cytometry, ELISA, Neutralization 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 동결건조형 항체로, 보존제 없이 PBS와 트레할로스 버퍼에 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
| ELISA (ELISA) | 0.1–0.4 µg/mL (Detection), 2–8 µg/mL (Capture) |
| Neutralization (Neu) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 110416 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18 (Gln26–Glu161, Thr43Ala) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576303 |
Product Specific Information
- This antibody does not cross-react with recombinant human (rh) 4-1BB, recombinant mouse (rm) 4-1BB, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFAS, rmGITR, rhHVEM, rhLymphotoxin R beta, rmLymphotoxin R beta, rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg antibody (LAL method).
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is encoded by the TNFRSF18 gene located at 1p36.33. This receptor, part of the TNF-receptor superfamily, shows increased expression upon T-cell activation and plays a key role in maintaining immunological self-tolerance via CD25(+)CD4(+) regulatory T cells. Knockout studies in mice suggest its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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