Thermo Fisher Scientific Rad18 Polyclonal Antibody
Rabbit 유래 다클론 항체로, Human RAD18 단백질을 인식합니다. Western blot 및 Immunoprecipitation에 사용 가능합니다. 액상 형태로 제공되며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 445 and 495 of Human E3 ubiquitin-protein ligase RAD18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Human Rad18 (hRad18) is a homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair during gap-filling of the daughter strand after replication of damaged DNA. The Rad6–Rad18 interaction is critical in the early steps of lesion bypass. In vivo, Rad18 forms a tight complex with Rad6 through a conserved ring-finger motif. The Rad18–Rad6 complex binds to damaged sites via the single-stranded DNA binding property of Rad18, followed by degradation of stalled replication components through the ubiquitin-conjugating enzyme activity of Rad6.
The human RAD18 gene maps to chromosome 3p24–25, a region often deleted in lung, breast, ovary, and testis cancers. It encodes a 495-amino-acid protein with a predicted molecular weight of 56 kDa and is ubiquitously expressed in various human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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