Thermo Fisher Scientific SHARPIN Polyclonal Antibody
SHARPIN 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot과 IHC(P)에서 사용 가능하며, 인간, 생쥐, 랫트 반응성. NF-κB 신호 조절 연구에 적합. 고순도 Affinity chromatography 정제, -20°C 보관.
- 카탈로그번호
- PA599964
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SHARPIN (Accession Q9H0F6), corresponding to amino acid residues G66–V116 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818897 |
Product Specific Information
Antibody detects endogenous levels of total SHARPIN.
Target Information
Component of the LUBAC complex, which conjugates linear polyubiquitin chains to substrates and plays a key role in NF-κB activation and inflammation regulation.
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1, participating in canonical NF-κB and JNK signaling pathways.
This ubiquitination prevents TNF-induced cell death and inflammation.
LUBAC is recruited to the TNF-R1 signaling complex following polyubiquitination by BIRC2/BIRC3, stabilizing the complex.
Together with FAM105B/otulin, LUBAC also regulates canonical Wnt signaling during angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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