Thermo Fisher Scientific Klotho Polyclonal Antibody
Klotho 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 인간, 생쥐, 랫트 반응성. PBS 및 50% glycerol 용액 형태로 제공되며, -20°C 보관. 노화 관련 연구 및 Klotho 단백질 발현 분석에 적합.
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- PA599961
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KL (Accession Q9UEF7), corresponding to amino acid residues Y204–A254 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818894 |
Product Specific Information
Antibody detects endogenous levels of total Klotho.
Target Information
KLOTHO is a systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, deficiency in KLOTHO expression leads to aging-like phenotypes such as arteriosclerosis, osteoporosis, and skin atrophy, along with growth retardation, short lifespan, and infertility. Transgenic mice overexpressing KLOTHO show an extended lifespan by inhibiting insulin/IGF1 signaling. KLOTHO is also involved in regulating calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D and has been identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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